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Romaine I Fernando Selected Research

Brachyury protein (Brachyury)

11/2017Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury.
3/2015Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody.
5/2014Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis.
5/2014WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition.
10/2013Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine.
9/2013An autocrine loop between TGF-β1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype.
7/2012Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer.
6/2012Cancer vaccines targeting the epithelial-mesenchymal transition: tissue distribution of brachyury and other drivers of the mesenchymal-like phenotype of carcinomas.
8/2011IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells.
5/2011Strategies to target molecules that control the acquisition of a mesenchymal-like phenotype by carcinoma cells.
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Romaine I Fernando Research Topics

Disease

17Neoplasms (Cancer)
11/2017 - 04/2007
12Carcinoma (Carcinomatosis)
07/2016 - 04/2007
6Neoplasm Metastasis (Metastasis)
02/2015 - 04/2007
4Breast Neoplasms (Breast Cancer)
03/2015 - 10/2003
2Lung Neoplasms (Lung Cancer)
07/2016 - 07/2012
1Vaccinia
11/2017
1Diarrhea
11/2017
1Uterine Cervical Neoplasms (Cancer of the Cervix)
01/2017
1Hemangioblastoma
03/2015
1Chordoma
03/2015
1Adenocarcinoma
07/2012
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
07/2012
1Neurodegenerative Diseases (Neurodegenerative Disease)
06/2003
1Alzheimer Disease (Alzheimer's Disease)
06/2003
1Pelvic Floor Disorders
06/2003
1Inflammation (Inflammations)
06/2003

Drug/Important Bio-Agent (IBA)

12Brachyury protein (Brachyury)IBA
11/2017 - 04/2007
10Transcription Factors (Transcription Factor)IBA
11/2017 - 04/2007
4VaccinesIBA
11/2017 - 10/2013
4Proteins (Proteins, Gene)FDA Link
01/2017 - 06/2003
3Neoplasm Antigens (Tumor Antigens)IBA
06/2016 - 04/2007
3CytokinesIBA
06/2012 - 06/2003
2EpitopesIBA
01/2017 - 04/2007
2Interleukin-8 (Interleukin 8)IBA
07/2016 - 08/2011
2ErbB Receptors (EGF Receptor)IBA
07/2016 - 07/2012
2TamoxifenFDA LinkGeneric
03/2015 - 05/2014
2Phosphotransferases (Kinase)IBA
05/2014 - 07/2012
2ChemokinesIBA
06/2012 - 08/2011
2Cancer VaccinesIBA
06/2012 - 05/2011
1B7 AntigensIBA
11/2017
1AutoantigensIBA
11/2017
1p38 Mitogen-Activated Protein KinasesIBA
07/2016
1Gefitinib (Iressa)FDA Link
07/2016
1Erlotinib Hydrochloride (CP 358,774)FDA Link
07/2016
1epacadostatIBA
06/2016
1Monoclonal AntibodiesIBA
03/2015
1Cyclin D1IBA
02/2015
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
02/2015
1Apoptosis Regulatory ProteinsIBA
02/2015
1Cadherins (E-Cadherin)IBA
02/2015
1Docetaxel (Taxotere)FDA Link
05/2014
1Messenger RNA (mRNA)IBA
05/2014
1AntigensIBA
05/2014
1Effector CaspasesIBA
05/2014
1LaminsIBA
05/2014
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2012
1HLA-A*02:01 antigenIBA
04/2007
1Estrogens (Estrogen)FDA Link
10/2003
1Cyclin-Dependent Kinases (cdk Proteins)IBA
10/2003
1LH Receptors (LH Receptor)IBA
06/2003
1Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric
06/2003

Therapy/Procedure

10Therapeutics
11/2017 - 02/2010
6Drug Therapy (Chemotherapy)
05/2014 - 05/2011
2Radiotherapy
05/2014 - 01/2014
1Immunotherapy
04/2007